温彬宇，副研究员，硕士生导师，加拿大多伦多大学访问学者。教育部全国研究生教育评估监测专家库专家，中国知网评审专家。博士毕业于西安交通大学，师从贺浪冲教授，主要从事中药活性成分筛选及作用机制研究。曾在中国中医科学院中药研究所从事博士后研究工作。主持国家及省部级课题2项，并以第一或通讯作者发表SCI论文10余篇。担任Pharmaceutical Biology、Toxicology Research，Analytical Letters等多个SCI收录杂志特约审稿人。

研究领域：中药活性物质筛选及其作用机制研究

通讯地址：北京市丰台区方庄芳星园1区6号东方医院东楼南支532

邮政编码：100078

电话号码：010-67689634

E-mail：wen-binyu@163.com 

主持、主研科研项目情况：

1、北京中医药科技发展资金项目（JJ-2020-39）, 基于肠道菌群-药动学-代谢组学整体观探讨白毛夏枯草-茯苓药对抗乳腺癌转移的药效物质基础及协同作用机制，结题，主持

2. 国家自然科学基金面上项目（81973786），地黄饮子由PERK/eIF2α通路调控“内质网应激-自噬偶联网络”失衡治疗阿尔茨海默病的机制研究，结题，主研 (排名2)

3、北京中医药大学，中央高校基本科研业务费，2016-JYB-JSMS-046，基于RAGE靶点探寻当归芍药散抗阿尔茨海默病活性成分研究，结题，主持

4、国家自然科学基金青年项目（81503347），基于体内外代谢产物及UGT1A1 抑制作用探索何首乌肝毒性机制及毒效物质基础，结题，主研 (排名2)

5、国家自然科学基金青年项目（81302981），基于ER/EGFR 途径交互调控探讨"白毛夏枯草-茯苓"药对治疗乳腺癌转移疗效与不同分子表型差异的相关性，结题，主研 (排名3)

6、中国博士后科学基金面上基金（2013M540913），基于探针药物法研究筋骨草提取物与CYP450酶相互作用，结题，主持

近年作为第一或通讯作者发表的代表性学术成果

1. Jiahui Qian#, Xinyu Zhao#, Siyuan Yuan#, Sijia Su, Chang Chen, Xu Tang, Junfeng Gao, Siye Men, Binyu Wen*. Metabolome-microbiome insights into therapeutic impact of 8-O-acetylharpagide against breast cancer in a murine model [J]. Biomedical Chromatography, 2024, e5880. https://doi.org/10.1002/bmc.5880.

2. Chen Chang, Qian Jiahui, Zhao Xinyu, Han Xuyang, Tang Xu, Gao Junfeng, Liu Yan, Jiang Jinzhu, Wen Binyu*. Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach[J]. Biomedical Chromatography, 2022, e5469

3. Jian Gao#, Ning Shi#, Hongju Guo, Junfeng Gao, Xu Tang, Siyuan Yuan, Jiahui Qian, Binyu Wen*. UPLC-Q-TOF/MS-Based Metabolomics Approach to Reveal the Hepatotoxicity of Emodin and Detoxification of Dihydromyricetin[J]. ACS Omega. 2021, 6(8), 5348-5358. 

4. Deng Zhihao, Yan Yan, Zhao Baoming, Wang Rui, Wang Xiaofeng, Chen Haoxuan, Wen Binyu*. Identification of the active ingredients from Guangtongxiao decoction in rat bile based on ultra-performance liquid chromatography/Synapt G2 quadrupole time-of-flight tandem mass spectrometry[J]. Journal of Traditional Chinese Medicine. 2020, 40(6), 999-1006. 

5. Lanlan Wu#, Chang Chen#, Yongbiao Li, Cong Guo, Yuqing Fan, Dingrong Yu, Tinglan Zhang, Binyu Wen*, Zhiyong Yan*, An Liu*. UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals the Anti-Ischemic Stroke Mechanism of Nuciferine in MCAO Rats[J]. ACS Omega. 2020, 5 (51), 33433-33444.

6. Yan Yan#, Ning Shi#, Xuyang Han, Guodong Li, Binyu Wen*, Jian Gao*. UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicity and Nephrotoxicity in Rats Induced by Polygonum multiflorum Thunb[J]. ACS Omega. 2020, 5(18), 10489-10500.

7. Yan Yan#, Kang Wang#, Xu Tang, Jun-feng Gao, Bin-yu Wen*. Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway. Toxicology Research, 2019, 8, 1028-1034.